The family of Cynthia Tisdale said she was a substitute teacher who worked two jobs to help pay for the medical expenses of her terminally ill husband.
The 63-year-old had an intense love for her family and helping others, along with a lust for life, they said.
She is the mother of a League City, Texas police detective.
"Since my brother has been very ill the last couple of years, she was a very excellent caregiver and she worked two jobs for extra income to help," Baptist pastor John Tisdale said, according to the McAllen Monitor. "She worked at the school and a second job as a server at night at an Italian restaurant chain."
Her brother-in-law posted on Facebook that she left a note for her husband before she left home Friday morning.
"Had to go meet teacher. I love you. Hope you feel better today. Left you breakfast," the note said.
Sabika Sheikh, a 17-year-old exchange student from Pakistan, came to Santa Fe High last August.
Her father, Abdul Aziz Sheikh, told The Associated Press from his home in Karachi that his daughter was to return home for Eid al-Fitr in a few weeks.
When he heard the news of the shooting, he frantically tried to call his daughter and her friends to find out whether she was safe. He was later told through her exchange agency that she had been killed.
"We are still in a state of denial. We can't believe it. It's like a nightmare," he said.
He said that his daughter was an accomplished student who hoped to one day work for Pakistan's Foreign Office.
"One should not lose his heart by such kind of incidents," he said. "One should not stop going for education to the U.S. or U.K., or China, or anywhere. One must go for education undeterred. But controlling such incidents is the responsibility of the respective governments."
Known for her fiery red hair, Angelique Ramirez was among those killed in the shooting, her family told KHOU-TV.
The 15-year-old girl's aunt, Sylvia Pritchett, posted on Facebook after putting a call out for help to find her niece who she was told had been shot in the leg.
"With a broken heart and a soul that just can't process all this right now, I have to announce my niece was one of the fatalities," Pritchett said. "Please keep all the families in your thoughts, and hug your children tightly."
Kimberly Jessica Vaughan
Kimberly Jessica Vaughan was reported missing by her mother, Rhonda Hart, after the shooting.
"My daughter was in first period art class at Santa Fe high school today," she posted on Facebook. "There was a shooter. I have not found her. Pass this along."
Hours later, Hart urged her Facebook friends to call their congressmen and senators.
"We need GUN CONTROL. WE NEED TO PROTECT OUR KIDS," she said.
Christopher Stone, 17, was an offensive lineman on the Santa Fe High football team, according to the Austin American-Statesman.
He was sitting in art class when he was gunned down and killed.
His sister, Angelica Stone, identified him as one of the victims.
"I will never understand why you were ripped from us in this way. But I want my brother to be remembered as the sweet, funny, dancing, singing, football-playing young man that we all knew and loved," she said.
Shana Fisher, who turned 16 this month, was also in art class when the shooting began.
Her mother, Sadie Rodriguez, said Fisher had rejected the shooter's romantic advances a week before the attack.
"She finally stood up to him and embarrassed him" in class, she said.
Rodriguez described her daughter as a "shy and sweet" girl with a passion for video games.
"She had a lot of love in her heart," her mother told the Houston Chronicle.
Glenda "Ann" Perkins
Glenda Ann Perkins was a substitute teacher at Santa Fe High School, which meant, in a way, that she was everybody's teacher.
"She really connected with the kids," sophomore Kyle Harris said. "She was an absolute angel."
Zachary Muehe, another sophomore, said Perkins was "everyone's favorite substitute," even among students who had graduated.
Muehe was in art class Friday morning when the shooting began, and he said he saw Perkins in the classroom next door as he tried to escape.
Christian Riley Garcia
Christian Riley Garcia was identified as one of the victims by Pastor Keenan Smith at Crosby Church who posted a memorial to Garcia on Facebook.
"The violence at Santa Fe High hit us all, but Crosby Church unites together in prayer for all the families affected and we mourn the loss of our own student Christian Riley Garcia 15 years old," Smith said.
In his post, Smith shared a photo of Garcia standing with his arm around a wall frame with a Bible verse written on it.
"Here is Riley about ten days ago writing scripture on the door frame of what was to be his new bed room." the post said. "Riley you are greatly loved and greatly missed."
Aaron Kyle McLeod
McLeod, a freshman who went by Kyle, could always be counted on to make light of any situation, his friend Kali Reeves said.
Reeves, 15, said she knew McLeod for years and became close friends with him in the eighth grade. She said he always had a smile on his face and loved to hang out with his friends.
"He was never one to be a sad or down person, he always had to joke or laugh about things," she said. "He was just outgoing and super sweet."
Reeves heard that her friend had been shot as she was fleeing from Santa Fe High School.
Reeves said she texted McLeod throughout the day to check up on him. She sent him one final text, saying she hopes he "gets better." Shortly after, she checked Facebook and learned he was one of the 10 killed.
Jared Conard Black
Jared Black's favorite class was art, his family said, and that was where he was Friday morning. He had turned 17 earlier in the week, and he couldn't wait for his birthday party Saturday.
A family friend said Jared's father, Robert Black, had wondered aloud how this could happen to someone like Jared.
"He would never hurt anyone," Elizabeth McGinnis recalled Jared's father saying.
Nick Black, Jared's half brother, said he wished he could see him one more time.
"My brother loved to play Minecraft on Xbox, play Pokemon Go on his cellphone, and loved art," Black said in a statement he wrote with a close friend. "We miss him so much."